Diabetes Research Group Seminar Series Lecture on Genetic and epigenetic regulation of liver metabolism and diseases – October 19, 2016


The IUB Diabetes Research Group would like to invite you to a seminar as part of the Indiana University-Bloomington Diabetes Research Group Seminar Series.


All are welcome to attend. Snacks and drinks will be provided.


Event:  Seminar talk by Charlie Dong, PhD, Associate Professor and Showalter Scholar, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine – Indianapolis, Investigator, Indiana University Center for Diabetes and Metabolic Diseases

Title:  “Genetic and epigenetic regulation of liver metabolism and diseases”

Date:  Wednesday, October 19, 2016

Time:  2:00-3:00 pm

Where:  Social Science Research Commons Grand Hall (Woodburn Hall 200), 1100 E. 7th Street, Bloomington, IN



Metabolism is highly coordinated by genetic, epigenetic, and environmental factors. Forkhead box O3 (FOXO3) transcription factor and sirtuin 6 (SIRT6) histone deacetylase are two key genetic and epigenetic factors that interface with environmental factors including diet. FOXO3 and SIRT6 control glucose, triglyceride, and cholesterol homeostasis. In chronic fatty liver disease, patatin like phospholipase domain containing 3 (PNPLA3) is best characterized gene that is strongly associated with hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Understanding the underlying molecular mechanisms are key to therapeutic development.



Dr. Dong’s research focuses on the pathogenesis of diabetes and obesity and related complications including fatty liver disease. Specifically, his laboratory investigates the pathophysiological functions of forkhead box O transcription factors (Foxos) and NAD+-dependent deacetylases (sirtuins) using cellular and animal model systems. His group is among the first to discover the link from the insulin signaling pathway to the NAD biogenesis and regulation. He also made significant contributions to the molecular mechanisms of triglyceride and cholesterol homeostasis, especially with regard to the role of Foxo3 and Sirt6 genes. Recently, his research has demonstrated a novel role of Sesn3 in the regulation of mTOR signaling and insulin sensitivity. In addition, his lab has uncovered a novel function of Sirt6 in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells. His research is supported by multiple NIH grants. His work has been published in the top-tier journals in the metabolic field, including Cell Metabolism, Diabetes, Diabetologia, Journal of Lipid Research, Molecular Metabolism, Journal of Biological Chemistry, and American Journal of Physiology – Endocrinology and Metabolism. Dr. Dong serves as reviewer for a number of journals including Nature Medicine, Nature Communications, Cell Metabolism, Diabetes, Diabetologia, Hepatology, and Scientific Reports. He also serves on NIH study sections.



Life Cycles: The Spotted Salamander – Lecture TODAY at 7pm in Myers Hall 130

Distinguished Professor Roger Hangarter (IU Biology) and Betsy Stirratt, curator of Grunwald Gallery, use photos and films to examine the intersection of beautfy , science and appreciation of local biodiversity in a series of monthly discussions. October’s offering is “Life Cycles: The Spotted Salamander.”

Life consists of cycles within cycles, complex interactions between organisms, sex, birth, death, and sometimes violence. In this lecture we will explore various aspects of beauty revealed by an examination of the life cycle of the spotted salamander, Ambystoma maculatum, the largest salamander in our region. This lecture is part of Themester 2016’s Biodiversity Lecture Series.

About this series:
Biological diversity is astonishing in its scope, beauty, and importance. With increasing urbanization and the pervasiveness of technology, humans are becoming more and more alienated from the nature system we are part of. Indeed, many people today only know about nature through virtual experiences delivered through television or the internet.

The growing detachment of humans from the natural world we inhabit has become known as “nature deficit syndrome.” In an effort to overcome the nature deficit syndrome, we will present a series of monthly lecture presentations that will focus on the beauty and science of the natural history that we have in Bloomington and our surrounding areas (within a 50-mile radius of Bloomington).

The presentations will be based on photographs and movie clips of our regional biology that will provide the audience with the opportunity to learn about the spectacular biodiversity our local environment offers. The motivation is to awaken a healthy awareness of our surroundings, generate an interest in learning more about the ecosystem we inhabit, and to encourage people to explore and contemplate on their own the beauty and wonder of Indiana’s ample and diverse nature. We hope to convince members of the audience there is no need to travel to exotic locations to find “nature.”