Diabetes Research Group Seminar Series Lecture on Genetic and epigenetic regulation of liver metabolism and diseases – October 19, 2016


The IUB Diabetes Research Group would like to invite you to a seminar as part of the Indiana University-Bloomington Diabetes Research Group Seminar Series.


All are welcome to attend. Snacks and drinks will be provided.


Event:  Seminar talk by Charlie Dong, PhD, Associate Professor and Showalter Scholar, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine – Indianapolis, Investigator, Indiana University Center for Diabetes and Metabolic Diseases

Title:  “Genetic and epigenetic regulation of liver metabolism and diseases”

Date:  Wednesday, October 19, 2016

Time:  2:00-3:00 pm

Where:  Social Science Research Commons Grand Hall (Woodburn Hall 200), 1100 E. 7th Street, Bloomington, IN



Metabolism is highly coordinated by genetic, epigenetic, and environmental factors. Forkhead box O3 (FOXO3) transcription factor and sirtuin 6 (SIRT6) histone deacetylase are two key genetic and epigenetic factors that interface with environmental factors including diet. FOXO3 and SIRT6 control glucose, triglyceride, and cholesterol homeostasis. In chronic fatty liver disease, patatin like phospholipase domain containing 3 (PNPLA3) is best characterized gene that is strongly associated with hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Understanding the underlying molecular mechanisms are key to therapeutic development.



Dr. Dong’s research focuses on the pathogenesis of diabetes and obesity and related complications including fatty liver disease. Specifically, his laboratory investigates the pathophysiological functions of forkhead box O transcription factors (Foxos) and NAD+-dependent deacetylases (sirtuins) using cellular and animal model systems. His group is among the first to discover the link from the insulin signaling pathway to the NAD biogenesis and regulation. He also made significant contributions to the molecular mechanisms of triglyceride and cholesterol homeostasis, especially with regard to the role of Foxo3 and Sirt6 genes. Recently, his research has demonstrated a novel role of Sesn3 in the regulation of mTOR signaling and insulin sensitivity. In addition, his lab has uncovered a novel function of Sirt6 in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells. His research is supported by multiple NIH grants. His work has been published in the top-tier journals in the metabolic field, including Cell Metabolism, Diabetes, Diabetologia, Journal of Lipid Research, Molecular Metabolism, Journal of Biological Chemistry, and American Journal of Physiology – Endocrinology and Metabolism. Dr. Dong serves as reviewer for a number of journals including Nature Medicine, Nature Communications, Cell Metabolism, Diabetes, Diabetologia, Hepatology, and Scientific Reports. He also serves on NIH study sections.